Lipinski Rule (Pfizer Rule)
What kind of compound become drugs ? The drug follow the Lipinski Rule (Pfizer Rule) 1- Substance should have molecular weight of 500 or less. 2- It should be fewer than five H-bond donating function and fewer then and ten hydrogen bond accepting function. 3- The substance should be calculated LogP between 1 and 5. Where LogP = Partial Coefficent (P) P = [Water/Aqueous] / [Octanol]